Gelatin fluid requirement

The high specificity required for the analysis of physiological fluids often necessitates the incorporation of permselective membranes between the sample and the sensor. A typical configuration is presented in Fig. 7, where the membrane system comprises three distinct layers. The outer membrane. A, which encounters the sample solution is indicated by the dashed lines. It most commonly serves to eliminate high molecular weight interferences, such as other enzymes and proteins. The substrate, S, and other small molecules are allowed to enter the enzyme layer, B, which typically consist of a gelatinous material or a porous solid support. The immobilized enzyme catalyzes the conversion of substrate, S, to product, P. The substrate, product or a cofactor may be the species detected electrochemically. In many cases the electrochemical sensor may be prone to interferences and a permselective membrane, C, is required. The response time and sensitivity of the enzyme electrode will depend on the rate of permeation through layers A, B and C the kinetics of enzymatic conversion as well as the charac-... 

Gelatin is a plasma substitute. Plasma substitutes should not be used to maintain plasma volume in burns or peritonitis. In these scenarios albumin should be given. Close monitoring, including monitoring of fluid and electrolyte balance and urine output, is required in patients being administered plasma and plasma substitutes. Plasma substitutes should also be used with caution in patients with cardiac disease, liver disease or renal impairment. 

Finally, the particulate barrier did serve to absorb pools of blood ( 150x), adhered to the injured tissue and provide physical abrasion properties that may eventually be a compliment or pretreatment to a wound instead of an environmentally protective barrier dressing. A demonstration of rapid blood absorption by the barrier dressing is shown in Figs. 2.35-2.38. Theoretically, only seconds would be required to absorb fluid from bleeding wounds and form a protective gelatinous layer over the wound. 

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