Gefitinib interactions

Swaisland HC, Ranson M, Smith RP, et al. Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet 2005 44(10) 1067—1081. 

The KINOMEscan selectivity scores for a selection of the marketed kinase inhibitors demonstrate the potential for the type II inhibitors imatinib 7, sorafenib 8 and lapatinib 10 to display higher selectivity than the type I inhibitors sunitinib 3 and dasatinib 4, especially when only higher affinity off-target interactions are considered (S(100 nM) scores). It can also be seen that, despite their potential to inhibit multiple kinase family members, it is possible to achieve good levels of selectivity with type I inhibitors ([Pg.83]

Gefitinib In a retrospective study of 296 patients taking gefitinib for non-smaU-cell lung cancer, 12 also took warfarin there was a raised prothrombin time in six, associated with liver dysfunction [42. It is not clear to what extent a direct interaction of gefitinib with warfarin was responsible in these cases, as opposed to liver impairment. 

Drug-drug interactions Gtfitinib It has been reported in Korea that the use of complementary herbal medicines caused gefitinib treatment failure [73"]. 

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