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Gattermann aldehyde reaction Adams modification

This reaction, applicable only to the preparation of hydroxy-aldehydee, is alternative to the Gattermann aldehyde reaction (or the Adams modification of it) given under 4. The yields are usually smaller, but a large quantity of the phenol may be recovered. The following mechanism is consistent with the known facts ... [Pg.692]

For preparative purposes the Gattermann reaction is much more useful. It was first usedS5 to prepare ethyl 2-formyl-3,5-dimethyl- and ethyl 3-formyl-2,5-dimethyl-pyrrole-4-carboxylate, by means of hydrogen cyanide and hydrogen chloride in ether. Later applications sometimes involved minor changes such as the use of chloroform as solvent, or of Adams modification of the reaction . Formylation generally occurs at an a-position, but if none is open there is usually no difficulty in jS-substitution. Pyrrole-2-aldehyde cannot be made this way, for it reacts further to form dyestuffs, but several 1-alkylpyrroles have been satisfactorily formylated . The initial... [Pg.63]


See other pages where Gattermann aldehyde reaction Adams modification is mentioned: [Pg.415]    [Pg.184]   
See also in sourсe #XX -- [ Pg.690 , Pg.701 , Pg.702 ]

See also in sourсe #XX -- [ Pg.690 , Pg.701 , Pg.702 ]




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Adams modification

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Gattermann reaction

Gattermanns reaction

Modification reaction

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