Gastrointestinal toxicity of 5-fluorouracil

Shirasaka T, Shimamoto Y, Fukushima M. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its anti-tumor activity in rats. Cancer Res 1993 53 4004 009. 

The gastrointestinal toxicity of 5-fluorouracil is well documented and often dose-limiting. However, in a retrospective 10-year survey of gastrointestinal function in 19 patients who also had inflammatory bowel disease, although it did appear to increase the risk of exacerbation of diarrhea, it was not totally conclusive, as it was difficult to evaluate the contribution of other potentially causative factors, such as radiation (88). 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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