Gastroesophageal reflux disorder drugs

The Hj-receptor blockers include cimetidine, famotidine, and ranitidine. These drugs are used to decrease gastric acid secretion in the treatment of peptic ulcer, gastroesophageal reflux disorder, and hypersecretory conditions, such as Zollinger-ElUson syndrome. The pharmacodynamics and clinical uses of these drugs are discussed in Chapter 40. 

Cimetidine is indicated for the treatment of disorders associated with hypersecretion of gastric acid, for example, gastric and duodenal ulcer disease, gastroesophageal reflux. The drug competitively antagonizes the H-2 receptor of the parietal cells. 

Cisapride, a 5-HT4 agonist, was used in the treatment of gastroesophageal reflux and motility disorders. Because of toxicity, it is now available only for compassionate use in the USA. Tegaserod, a 5-HT4 partial agonist, is used for irritable bowel syndrome with constipation. These drugs are discussed in Chapter 62. 

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