Gastroesophageal reflux disease clinical presentation

There appears to be a higher incidence of asthma in children with gastroesophageal reflux disease (prevalence estimated to be 34-89 %), and this has prompted the suggestion, and the belief seemingly supported by some studies, that PPI treatment of these children may lead to an improvement in asdima symptoms. Three randomized trials showed that PPIs had a beneficial effect on asthma symptoms but one randomized, double-blind, placebo-controlled trial failed to show that omeprazole improved symptoms. At present, there is not enough data from well constructed and controlled clinical trials to reach a confident and conclusive decision on this question. 

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