Gastrinoma diagnosis

Goetze JP, Rehfeld JF. Impact of assay epitope specificity in gastrinoma diagnosis. Clin Chem 2003 49 333-4. 

Indications Diagnosis of gastrinoma (Zollinger-Ellison syndrome)... 

As already mentioned, measurement of gastrin in plasma has so far had a minor but well-defined place in clinical biochemistry in the diagnosis, localization, and control of the therapy of gastrinomas associated with the Zollinger-Ellison syn-... 

Cardiovascular A 17-year-old man with a 3-year history of ulcer symptoms, diarrhea, and bouts of abdominal colic developed severe hypotension (50/20 mmHg) after receiving intravenous metoclopramide for acute vomiting with diarrhea [9 ]. He then developed pneumonia, rhabdomyolysis, renal tubular necrosis, and disseminated intravascular coagulation. A diagnosis of gastrinoma was made. During hormonal assessment, he received a second dose of... 

Gastrin-producing cells are not evident in the adult pancreas, yet gastrinomas were previously considered to be predominantly pancreatic endocrine tumors. Currently, it is apparent that at least 50% of the lesions occur in the duodenum. In much the same fashion as carcinoid tumors, the majority of lesions are metastatic or multiple at diagnosis. 

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