Gastric secretion acute model

In early infection, acid secretion decreases, and at least two acid-inhibitory substances have been purified from H. pylori, with one partially sequenced. It appears to represent a metabolic gene. There is inevitably an acute gastritis observed in animal models, with ingress of a variety of inflammatory cells into the submucosa. The reason for the gastritis is obscure, but it is found after infection by any strain of H. pylori. It seems possible that NH3 production is the explanation, because all strains that are infective produce large quantities of NH3 that would tend to alkalinize the interior of gastric epithelial cells. 

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