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Gardneria alkaloids

Recently, the structure of gardfloramine of Gardneria multiflora was determined by X-ray crystallography. This compound has three oxygen functions on its aromatic moiety the positions of oxygen atoms were proved to be at C-9 [Pg.243]

Plants of the G. multiflora group do not contain gardnerine (1) or its derivatives, which are characterized by their typical indole chromophore. The main constituent, gardneramine (4), and various accompanying alkaloids are all at the oxidation level of oxindole. As shown in Table HI, thirteen monomeric and two dimeric Gardneria alkaloids have been isolated, and most of the structures were elucidated through chemical correlation with the established structure of 4 165,166,169,172). [Pg.55]

The structure of gardfloramine has recently been established as formula 27 by the use of X-ray crystallography. It is interesting to note that 27 has a pattern of oxidation on the aromatic ring different from that of gardneramine (4) and all other trimethoxylated Gardneria alkaloids (177). [Pg.56]

The H-NMR signal arising from the C-18 methyl group on the chitosenine part of gardmultine (28) is observed at 80.88 as a doublet. This anomalous high-field chemical shift can be explained by the anisotropic [Pg.58]


Details of the structure elucidation of gardneramine and 18-demethyl-gardneramine have now been published these and other Gardneria alkaloids figure prominently in an account of Sakai s own investigations on indole alkaloids of Japanese plants. [Pg.219]

Hara et al. demonstrated a systematic approach to solvent system optimization with the separation of a series of uncaria and Gardneria alkaloids. [Pg.343]

RSP,yOh,Uncaria and Gardneria alkaloids Solvent system optimization procedure Spherosil X0A-600, 5 ym or Wakogel LCH-10, 10ym 100x0.5 n-hexane-THF, CH.Cl.-DEA, CHCl.-MeOH, THF-MeOH in varibus ratios J Stepgradient CH,Cl,-Me0H-DEA(100 0.1 0.01) to (100 110.6l) 42 ... [Pg.348]

Scheme I. Gardneria alkaloids isolated from Gardneria nutans Sieb. et Zucc. Scheme I. Gardneria alkaloids isolated from Gardneria nutans Sieb. et Zucc.
Gardneramine (4) exhibits a mild central depressive effect, while the comparable effect of gardnerine (1) is much weaker. A medium grade of acute toxicity was found for Gardneria alkaloids. Low toxicity was observed for hydroxygardnutine (3), which should be compared with that of gardnutine (2) (176) (Table IV). [Pg.62]

Sakai S, Aimi N, Yamaguchi K, Yamanaka E, Haginiwa J 1982 Gardneria alkaloids. Part 13. Structure of gardmultine and demethoxygardmultine bis-type indole alkaloids of Gardneria multiflora Makino. J Chem Soc Perkin I 1257-1262... [Pg.255]

Sakai S, Aimi N, Yamaguchi K, Ogata K, Haginiwa J 1987 Gardneria alkaloids. Part 14. The structure of gardfloramine and 18-demethoxygardfloramine. Chem Pharm Bull 35 453-455... [Pg.255]


See other pages where Gardneria alkaloids is mentioned: [Pg.243]    [Pg.414]    [Pg.291]    [Pg.356]    [Pg.1]    [Pg.1]    [Pg.2]    [Pg.47]    [Pg.47]    [Pg.52]    [Pg.62]    [Pg.62]    [Pg.263]    [Pg.428]    [Pg.380]    [Pg.386]    [Pg.249]    [Pg.19]    [Pg.392]    [Pg.344]    [Pg.172]    [Pg.324]    [Pg.242]    [Pg.243]    [Pg.263]    [Pg.383]    [Pg.218]   
See also in sourсe #XX -- [ Pg.47 ]




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