Gardneria multiflora

Gardmultine (C45H54N4O10) a bisindole alkaloid isolated from Gardneria multiflora Makino, comprises gardneramine and chitosenine linked by a spiro five-membered ring. The structure proposed from chemical and spectroscopic properties (50) was confirmed by the crystal-structure analysis (51). The structural formula and the stereodrawing, shown in Fig. 25, illustrate the spiro junction at atom C-16 between the two component alkaloids of gardmultine. 

Gardmultine (Alkaloid E), first isolated in 1970 from Gardneria multiflora, is composed of two typical monomeric Gardneria components, and thus has a structure... 

Several new alkaloids have been isolated from Gardneria multiflora Makino, and the structures of six of them, all closely related to gardneramine, have been elucidated. Alkaloid J has the structure (156) and Alkaloid L is the corresponding allylic alcohol (157). Alkaloid J can be obtained by hydrolysis of the... 

Recently, the structure of gardfloramine of Gardneria multiflora was determined by X-ray crystallography. This compound has three oxygen functions on its aromatic moiety the positions of oxygen atoms were proved to be at C-9... 

Sakai S, Aimi N, Yamaguchi K, Yamanaka E, Haginiwa J 1982 Gardneria alkaloids. Part 13. Structure of gardmultine and demethoxygardmultine bis-type indole alkaloids of Gardneria multiflora Makino. J Chem Soc Perkin I 1257-1262... 

Plants of the G. multiflora group do not contain gardnerine (1) or its derivatives, which are characterized by their typical indole chromophore. The main constituent, gardneramine (4), and various accompanying alkaloids are all at the oxidation level of oxindole. As shown in Table HI, thirteen monomeric and two dimeric Gardneria alkaloids have been isolated, and most of the structures were elucidated through chemical correlation with the established structure of 4 165,166,169,172). 

Extractions of Gardneria liukiuensis Matsushima showed that the alkaloid content is very similar to that of G. multiflora ... 

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