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Ganglioside biosynthesis, combinatorial

Kolter, T., Proia, R.L. and Sandhoff, K. (2002) Combinatorial ganglioside biosynthesis, journal of Biological Chemistry 277, 25859-25862. [Pg.420]

Fig. 1.4.7. Early steps in combinatorial ganglioside biosynthesis [9]. The sites of (indirect) inhibition by 11 and 12 are indicated. Abbreviations Cer, ceramide, N-acylsphingosine Clc, glucose Gal, galactose GalNAc, N-acetylgalactosamine NeuAc, N-acetylneuraminic acid SAT, sialyltransferase GalNAcT, N-acetylgalactosaminyltransferase ... Fig. 1.4.7. Early steps in combinatorial ganglioside biosynthesis [9]. The sites of (indirect) inhibition by 11 and 12 are indicated. Abbreviations Cer, ceramide, N-acylsphingosine Clc, glucose Gal, galactose GalNAc, N-acetylgalactosamine NeuAc, N-acetylneuraminic acid SAT, sialyltransferase GalNAcT, N-acetylgalactosaminyltransferase ...
Kolter T, Proia RL, Sandhoff K (2002) Combinatorial ganglioside biosynthesis. J Biol Chem 277 25859-25862... [Pg.1689]

Conformational restriction of biologically flexible molecules is a successful strategy in drug development. Application of this concept to ceramide, the membrane anchor of sphingolipids, led to the unexpected inhibition of glycosyltransferases involved in the combinatorial biosynthesis of gangliosides. This discovery offers a new approach to cell surface engineering. [Pg.48]

See other pages where Ganglioside biosynthesis, combinatorial is mentioned: [Pg.384]    [Pg.384]    [Pg.398]    [Pg.245]    [Pg.1676]   
See also in sourсe #XX -- [ Pg.384 ]



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