Gallium siderophore

Ga-citrate is also commonly used for imaging infection and inflammation. " At sites of inflammation, the gallium-transferrin complex leaks into the extracellular space and Ga is transchelated from transferrin in blood to lactoferrin and siderophores see Iron Transport Siderophores), which are released by leukocytes and bacteria. Imaging with Ga takes place usually 24-72h following injection. 

Emery T and Hoeeee PB (1980) Siderophore-medi-ated mechanism of gallium uptake demonstrated in the microorganism Ustilago sphaerogena. J Nucl Med 21 935-939. 

Van der Helm s group elucidated the structure of des(diserylgly-cyl)-ferrirhodin - a novel siderophore isolated from Aspergillus ochra-ceous (221). This is the first natural linear N -hydroxyomithine tripeptide to be isolated. Evidence for the structure was derived from and C-NMR spectra of its deferri form and the gallium complex and is also based on the synthesis of N-acetyl and methyl esters. 

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