Galactose receptor

J. Aqvist and S. L. Mowbray, Sugar recognition by a glucose/galactose receptor. 

Smedsrod, B., and M. Einarsson. 1990. Clearance of tissue plasminogen activator by mannose and galactose receptors in the liver. Thromb. Haemost. 63 60-66. 

Smedsrod B, Einarsson M, Peroft H. Tissue plasminogen activator is endocytosed by mannose and galactose receptors of rat liver cells. Thromb Haemostasis 1988 59 480-4. 

Ricin is a lectin-type globular glycoprotein and consists of A and B chains (Doan, 2004 Li and Pestka, 2008). Ricin is considered a Type 2 ribosome-inactivating protein (RIP) (Millard and LeClaire, 2008). The ricin B chain attaches to the plasma membrane at the galactose receptors, pits are... 

NMR Studies of Fluorinated Sugars Binding to the Glucose and Galactose Receptor... 

Figure 1. Sttucture of the E. coli D- glucose and D-galactose receptor. Shown is the (A) a-carbon backbone structure of the receptor with p-D-glucose in the sugar binding pocket and Ca(n) ion in the metal binding site. (B) illustrates the residues that are involved in binding the sugar in the pocket.

Luck, L. A., Vance, J. E., O Connell, T. M. and London, R. E. (1996) 19F NMR relaxation studies on 5-fluorotryptophan- and tetradeutero-5-fluorotryptophan-labeled E. coli glucose/ galactose receptor. Journal of Biomolecular NMR, 7, 261-272. 

Sialic acid is slowly removed from circulating Cp by tissue and plasma neuraminidases, resulting in exposure of the penterminai galactose residue on the carbohydrate side chains. Once a critical number of galactose residues are exposed, the protein is rapidly removed by galactose receptors of the hepatic parenchymal cells and catabofized. Markedly increased catabolism by this route may result in deposition of excessive copper in the liver. The normal plasma half-life of intact, holoCp (copper replete) is 4 to 5 days, whereas that of apoCp is a few hours and that of desia-lylated Cp a few minutes. 

Seymour L, Ulbrich K, Wedge S, Hume I, Strohalm J, Duncan R. N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor pharmacokinetics in DBA-2 mice. Brit J Cancer 1991 63 859-866. 

J. Aqvist and S. L. Mowbray,/. Biol. Chem., 270, 9978 (1995). Sugar Recognition by a Glu-cose/Galactose Receptor. Evaluation of Binding Energetics from Molecular Dynamics Simulations. 

L. W. Seymour, K. Ulbrich, S. R. Wedge, I. C. Hume, J. Strohalm and R. Dimcan, N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor — pharmacokinetics in Dba2 mice, Br. ]. Cancer, 63, 859-866 (1991). 

G. Gregoriadis and J. Senior, Targeting of small unilamellar liposomes to the galactose receptor lit vivo. Biochem. Soc. Trans., 12(2), 337-339 (1984). 

Glucose/Galactose Receptor. Evaluation of Binding Energetics from Molecular Dynamics Simulations. 

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