Galactose 1-phosphate, biosynthesis

See also UDP-Galactose 4-Epimerase, UTP, Glucose-l-Phosphate, Biosynthesis of Glycoconjugates, De Novo Pyrimidine Nucleotide Metabolism, Biosynthesis of Glycoconjugates... 

The biosynthesis of D-mannose involves the conversion of the D-gluco isomer via the D-fructo (as the 6-phosphates) by isomerization at C-2 differing from the conversions of other sugars (including D-galactose) which proceed via nucleoside diphospho sugars, the formation of which requires a supply of nucleoside triphosphates. However, despite the widespread distribution of D-mannose and its utilisation in glycolysis and... 

Leloir, L.F. (1951) The Enzymic Transformation of Uridine Diphosphate into a Galactose Derivative , Archives of Biochemistry and Biophysics, 33, 186-90 Leloir, L.F., Staneloni, R.J., Carminatti, H. Behrens, N.H. (1973) Biosynthesis of a N,N-diacetylchitobiose Containing lipid by Liver Microsomes. Probable Dolichol Phosphate Derivative , Biochemical and Biophysical Research Communications, 52, 1285-92... 

Figure 3.25 Biosynthesis of the 0-side Chain Polysaccharide in Salmonella anatum. At the inner face of the cytoplasmic membrane the nucleotide sugars are transferred in sequence to the C55 polyisoprenoid phosphate carrier lipid ( ). Following the transfer of the mannosylrhamnosyl-galactose trisaccharide-carrier lipid to the outer face of the membrane the trisaccharides polymerise forming the lipid-linked 0-antigen polymer, the polysaccharide portion of which is then passed to the lipid A core (A C). The liberated carrier lipid is then dephosphorylated and returned to the cytoplasmic face of the membrane.

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