Galactomannans model

The ability of certain galactomannans to form gel structures when mixed with these non-gelling polysaccharides implies that a network is formed by the interaction of unlike chains. Fiber diffraction evidence, and indications from computer model-building191,19- (dis-... 

Fig. 4. —Model Proposed for the Interaction Between Chains of K-Carrageenan and the regions of Galactomannan Sparsely Substituted with D-Galactosyl Groups.

A way of reconciling the observed proportions of mannobi-, tri-, and tetra-oses and heterosaccharides,16113 released by guar-seed jS-D-mannanase (from hot-water-soluble carob galactomannan), with this model, would be if the enzyme preferentially hydrolyzes appropriate, unsubstituted d-mannosyl residues (as in 31) then, it would only be able to hydrolyze on the reducing side of a substituted D-mannose (as in 32) if there were a... 

Interestingly, the antiviral activity of HS mimetics against flaviviruses was also demonstrated in vivo. Two sulfated galactomannans extracted from seeds of Mimosa scabrella and Leucaena leucocephala, named BRS and LLS, respectively, protected mice against intraperitoneal infection with YFV [91]. More recently, the oligosaccharide PI-88 was assayed in vitro and in murine models of flavivirus infection. This low molecular weight compound did not show in vitro effectiveness but ameliorated disease in JEV and DENV-2 infected mice,... 

Dea, I. C. M., McKinnon, A. A., and Rees, D. A. (1972). Tertiary and quaternary structure in aqueous polysaccharide systems which model cell wall cohesion reversible changes in conformation and association of agarose, carrageenan and galactomannans. J. Mol. Biol. 68 153-172. 

Richardson, P. H., Clark, A. H., Russell, A. L., Aymard, P. and Norton, I. T. 1999. Galactomannan gelation A thermal and rheological investigation analyzed using the cascade model. Macromolecules 32(5) 1519-1527. 

Figure 1. Proposed model for the interaction between the double helix of k-cot-rageenan or agarose with galactomannan...

Sittikijyothin W., Torres D., Goncalves M. P. 2005. Modelling the rheological behaviour of galactomannan aqueous solutions,... 

Wu Y., Li W., Cui W., Eskin N. A. M., Goff H. D. 2012. A molecular modeling approach to understand conformation functionality relationships of galactomannans with different mannose/galactose ratios. Food... 

Chandrasekaren R, Radha A. Molecular modeling of xanthan galactomannan interactions. Carbohyd Polym 1997 32 201-208. 

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