Gadolinium neutron-capture therapy

Tokumitsu H, Ichikawa H, Fukumori Y (1999) Chitosan-gadopenteic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer Preparation by novel emulsion-droplet coalescence technique and characterization. Pharm Res 16 1839-1835... 

Akine, Y, Tokita, N., Tokuuye, K., Satoh, M., Churei, H., Pechoux, C. L., Koba-yashi, T. and Kanda, K., Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy, ]pn. J. Cancer Res., 84,841,1993. 

The potential of gadolinium-loaded chitosan nanoparticles has been demonstrated. The potential of gadolinium neutron-capture therapy for cancer was evaluated using chitosan nanoparticles as a novel device. Later, the similar gadopentectic acid-loaded chitosan nanoparticles were prepared for gadolinium neutron-capture therapy. Their releasing properties and ability for long-term retention in the tumour indicated that these particles are useful as intratumoural... 

Against cancer gadolinium neutron-capture therapy was recently modified by com-plexing gadolinium with chitosan to retard the growth of solid [360], Gadolinium loaded chitosan nanoparticles for neutron-capture therapy was successfully reported for in vitro cellular accumulation of gadolinium [361]. 

Tokumitsu H, Hiratsrrka J, Sakurai Y, Kobayashi T, Ichikawa H, Fukumori Y. Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles in vivo growth suppression of experimental melanoma solid tumor. Cancer Lett. 2000 150(2) 177-82. 

Future Applications of Boron and Gadolinium Neutron Capture Therapy... 

M. Takagaki, N. S. Hosmane, Gadolinium neutron capture therapy for malignant brain tumors. Aino J., 2007, 6, 39. 

G. D. Stasio, P. Casalbore, R. Pallini, B. Gilbert, F. Sanita, M. T. Ciotti, G. Rosi et al., Gadohnium in human glioblastoma cells for gadolinium neutron capture therapy. Cancer Res., 2001,61,4272. 

M. Takagaki, Y. Oda, M. Matsumoto, H. Kikuchi, T. Kobayashi, K. Kanda, Y. Ujeno, Gadolinium neutron capture therapy for brain tumors - Biological Aspects. Biological Aspects of Brain Tumors, K. Tabuchi (Ed.), Springer-Verlag, 1991, p. 494. 

K. Wangerin, C. N. Culbertson, T. Jevremovic, A comparison of the COG and MCNP codes in computational neutron capture therapy modeling. Part II gadolinium neutron capture therapy models and therapeutic effects. Health Phys. 2005, 89, 135. 

J. T. Masiakowski, J. L. Horton, L. J. Peter, Gadolinium neutron capture therapy for brain tumors a computer study. Med. Phys., 1992,19, 1211. 

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