GABAergic system function

GABA (y-aminobutyric acid) is an amino acid with mostly inhibitory functions in the mammalian central nervous system. Structures involved in releasing or binding GABA as a neurotransmitter constitute the GABAergic system. The GABAergic system is involved... 

The first group includes the glutamatergic and GABAergic systems. These two classes of neurons are by far more prevalent and more widely distributed than any other neurotransmitter system in the human brain. The major functional implication of such widespread distribution is that the modulation of glutamatergic and GABAergic neurotransmission affects many neural systems. 

Similarly, presynaptic 5-HT3 receptors were suggested to control 5-HT release in various brain areas (Blier and Bouchard 1993), but this has also been disputed afterwards (Crespi et al. 1997). Taken together, with the exception of consistent reports concerning the GABAergic system, the possible roles and functions of presynaptic 5-HT3 receptors remains somewhat controversial (van Hooft and Vijverberg 2000). 

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