Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

GABAb postsynaptic

In the spinal cord GABA can also activate the G-protein-linked GABAb receptor, also found pre- and postsynaptically. Baclofen modulation of nociceptive transmission is seen under inflammatory conditions in animals but in humans the drug appears to lack any analgesic effect. [Pg.466]

Schuler, V., Liischer, C., Blanchet, C., et al. (2001) Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABAb responses in mice lacking GABAb1. Neuron 31,47-58. [Pg.109]

GABAB baclofen 2-OH saclofen Inhibitory (presynaptic) i Ca2+ conductance Inhibitory (postsynaptic) t K+ conductance... [Pg.459]

GABA receptors are divided into two main types GABAa and GABAB. inhibitory postsynaptic potentials in many areas of the brain have a fast and slow component. The fast component is mediated by GABAa receptors and the slow component by GABAB receptors. The difference in kinetics stems from the differences in coupling of the receptors to ion channels. GABAa... [Pg.463]

Baclofen GABAb agonist, facilitates spinal inhibition of motor neurons Pre- and postsynaptic inhibition of motor output Severe spasticity due to cerebral palsy, mulitple sclerosis, stroke Oral, intrathecal Toxicities Sedation, weakness... [Pg.595]

Electrophysiological studies in mammalian CNS suggested subtle distinctions between pre- and postsynaptic GABABRs (see Nicoll 2004 for a review). Stronger evidence that pharmacological differences may exist between GABAb presynaptic... [Pg.391]

Structural and Functional Diversity Between Presynaptic and Postsynaptic GABAb Receptors... [Pg.396]

See other pages where GABAb postsynaptic is mentioned: [Pg.516]    [Pg.516]    [Pg.519]    [Pg.798]    [Pg.233]    [Pg.242]    [Pg.244]    [Pg.246]    [Pg.293]    [Pg.931]    [Pg.35]    [Pg.134]    [Pg.135]    [Pg.138]    [Pg.71]    [Pg.268]    [Pg.346]    [Pg.25]    [Pg.21]    [Pg.463]    [Pg.511]    [Pg.724]    [Pg.222]    [Pg.373]    [Pg.391]    [Pg.391]    [Pg.397]    [Pg.397]    [Pg.397]    [Pg.397]    [Pg.398]    [Pg.436]    [Pg.497]    [Pg.195]    [Pg.35]    [Pg.450]    [Pg.460]    [Pg.486]    [Pg.516]    [Pg.516]    [Pg.519]    [Pg.798]   
See also in sourсe #XX -- [ Pg.253 , Pg.255 , Pg.256 , Pg.258 , Pg.263 ]



SEARCH



GABAb

© 2024 chempedia.info