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GABA regulation

Cole LM, Casida JE. 1986. Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore. Life Sci 39 1855-1862. [Pg.280]

One proposed mechanism for toxaphene-induced neurotoxicity is that it acts as a noncompetitive y-aminobutyric acid (GABA) antagonist at the chloride channel in brain synaptosomes. Substances that bind to the GABA-regulated chloride channel induce convulsions by inhibiting chloride flux thus allowing brain cells to depolarize and fire spontaneously. ... [Pg.688]

More recently, the new insecticide, fipronil (Figure 3.11), has been shown to act as a potent blocker of the GABA-regulated chloride channel. It is being used to control both foliar and soil insects9 whilst the avermectins and milbemycins can only be used against foliar pests. [Pg.56]

Acts as a potent blocker of the GABA-regulated chloride channel... [Pg.743]

Figure 7.21 Effects of fipronil on the GABA response in Xenopus oocytes showing that fipronil interferes with passage of chloride ions through the GABA-regulated chloride channel. (From Gant, D.B. et al., Rev. Toxicol., 2,141,1998. With permission.)... Figure 7.21 Effects of fipronil on the GABA response in Xenopus oocytes showing that fipronil interferes with passage of chloride ions through the GABA-regulated chloride channel. (From Gant, D.B. et al., Rev. Toxicol., 2,141,1998. With permission.)...
Boosts chloride conductance through GABA-regulated channels... [Pg.1]

Boosts chioride conductance through GABA-regulated channeis... [Pg.171]

Potent Insecticides Acting at the GABA-Regulated Chloride lonophore... [Pg.77]

The macromolecular complex containing GABA-regulated chloride channels also may be a site of action of general anesthetics, ethanol, inhaled drugs of abuse, and certain metabolites of endogenous steroids. [Pg.266]

See other pages where GABA regulation is mentioned: [Pg.73]    [Pg.623]    [Pg.500]    [Pg.49]    [Pg.487]    [Pg.135]    [Pg.1146]    [Pg.105]    [Pg.77]    [Pg.77]    [Pg.85]    [Pg.87]    [Pg.126]    [Pg.273]    [Pg.12]    [Pg.724]    [Pg.288]    [Pg.37]    [Pg.273]   


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GABA

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