G-Strophanthin

The cardenolides g-strophanthin (hRf 5-10), convallatoxin (hRj 30-35) and k-strophanthin (h/ j 50-55) immediately formed red-violet chromatogram zones that gradually faded. Hence, the reagent was not always suitable for quantitative work. 

Fig. 1 Chromatograms of reference substances (A) and of a lily of the valley extract (B) 1 g-strophanthin, 2 = convallatoxin, 3 = k-strophanthin...

The pharmacokinetics of cardiac glycosides (A) are dictated by their polarity, i.e the number of hydroxyl groups. Membrane penetrability is virtually nil in ouabain, high in digoxin, and very high in digitoxin. Ouabain (g-strophanthin) does not penetrate into cells, be they intestinal epithelium, renal tubular, or hepatic cells. At best, it is suitable for acute intravenous induction of glycoside therapy. 

Synonyms. G-Strophanthin Strophanthin-G Strophanthinum Strophanthoside-G Uabaina Ubaina. 

GRATIBAIN GRATUS STROPHANTHIN G-STROPHANTHIN OUABAGENIN-l-RHAMNOSID (GERM.W) OUABAGENIN-l-RHAMNOSIDE OUABAINE OUBAIN PUROSTROPHAN STROPHANTHIN G STROPHOPERM... 

White powder or crystals poisonous cardiac glycoside (g-strophanthin) from the seeds of the African trees Strophanthus gratus and Acokan-thera ouabaio. Used as a heart stimulant and by some African peoples as a dart poison. Blocks the Na+/K+-ATPase. 

Strophanthi grati semen (1) is characterized by g-strophanthin (Tl) as the main compound at R 0.1, with smaller amounts of sarmentosides at Rf 0.25-0.4 and glycosides above and below g-strophanthin. Strophanthi kombd semen (2) contains the k-strophantin-glycoside mixture , which consists of k-strophanthoside (R, 0.05/T7), k-strophanthin 3 (R, 0.25/T3) and erysimoside (Rf 0.2/T4), They form major bands, while helveticoside (Rf — 0.55/T5) and cymarin (Rf — 0.6/T6) are minor compounds. 

Strophanthus gratus (seed) G-Strophanthin Oubagenin Rhamnose... 

Cardiac glycosides are known to inhibit the active transport of cations in a number of tissues. Thus, ouabain (g-strophanthin) inhibits transport in erythrocytes (Glyim, 1957 Schatzmann, 1953), striated muscle (Johnson, 1956), brain slices (Wollenberg and Wahler, 1956), and other tissues. Whittam (1962) showed that 2.5 X ouabain maximally decreased the potassium content of slices of cerebral cortex of the rat. Digitoxin was active at 10" M (Berman, cited by McHwain, 1963). 

Synonyms 3-[ (6-Deoxy-a-L-niannopy ranosy Doxy ]-l, 5,11a, 14,19-pentahydroxy-card-20(22)-enolide G-strophanthin acocantherin uabaina ubaina Trade names Amoaud, Astrobain, Gratibain, Ouabaine, Purostrophan, Strodival, Strophoperm Use Cardiotonic HPLC ... 

---