FXR-Dependent Regulation of Basolateral Drug and Bile Acid Uptake

1 FXR-Dependent Regulation of Basolateral Drug and Bile Acid Uptake 

TABLE 10.1 Key Nuclear Receptors and Transcription Factors Beyond PXR and CAR Involved in Regulation of Drug Disposition 

Nuclear Receptor Expression Ligands Target Genes General Effects/Functional Impact 

RXRa (NR2B1) Ubiquitous All Irani-retinoic acid Ntcp, Mrp2, ASBT Heterodimeric binding partner of other NRs induction of drug and bile acid transporters 

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