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Future Impact of Cytotoxicity Testing

As occurred with the introduction of in vitro testing for adverse pharmacokinetic properties, implementation of in vitro cytotoxicity testing in drug discovery is likely to reduce later attrition in drug development by an order of magnitude. An indispensable tool will be HCA and a cytotoxicity model similar to that described above. Attendance at the numerous annual industry conferences on HCA indicates that [Pg.340]

Screening First-tier screen for potential for human target organ toxicity [Pg.341]

Chromosomal toxicity Replacement of manual in vitro miconudei test [Pg.341]

Mechanisms of toxicity Characterize and develop mechanistic understanding of a toxicity [Pg.341]

Biomarkers Translational safety biomarkers (e.g., mitochondrial toxicity can be detected in vitro and in vivo), phospholipidosis [37] [Pg.341]


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