Furocoumarins synthetic routes

New synthetic routes (Scheme 9) to photosensitive linear and angular furocoumarins, furoquinolones, furoquino-lines, and their analogs were the subject of a review <2004MOL50>. It focuses on the Fries rearrangement of acyloxyheteroarenes, like 70 — 71, the condensation of acylhydroxyheteroarenes with a-carbonyl compounds, like 72 73, and the transformations of dihydrofuroheteroarenes, like 74 75. 

The furan ring is a common structural motif present in many biologically active molecules and pharmaceutical substances. Accordingly, the development of efficient synthetic routes to produce furans has been a major research field for over a century. Transition-metal-catalyzed transformations are probably the most powerful tools presently available for preparing furans from readily accessible starting materials [47-56]. Alkynes have been widely employed as building blocks for this end. In this context, the first metal-mediated synthetic approach to furocoumarins involving... 

SYNTHETIC ROUTES TO FUROCOUMARIN DERIVATIVES CU2O (0.8 equiv.)... 

V.F. Traven, New synthetic routes to furocoumarins and their analogs a review. Molecules 9 (2004) 50-66. 

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