Furocoumarins Furanocoumarins

Furanocoumarins Also called furocoumarins, methoxypsoralens or bergaptenes. Found in cold-pressed citrus oils, e.g. bergamot. An oxygen-containing cyclic structure associated with phototoxicity on exposure to ultraviolet light. 

The whole herb of A. graveolens was reported to contain the new furanocoumarin, 5-[4"-hydroxy-3"-methyl-2"-butenyloxy]-6,7-furocoumarin, in addition to oxypeucedanin, oxypeucedanin hydrate, and falcarindiol. The whole herb also contains 9-hydroxypiper-itone glucosides,/)-menth-2-ene-l,6-diol, and 8-hydroxygeraniol. ... 

Furanocoumarins (furocoumarins) are subdivided into linear furanocoumarins (psoralens) and angular furanocoumarins (angelicins). Linear furanocoumarins (LFCs) or... 

Reversed-phase HPLC is the most widely to quantify furanocoumarins. The quantitative analysis of some furanocoumarins from P. sativa fruits was performed by RP-HPLC in system C18 eluted with methanol and water in gradient elution [42,43,76]. The quantitative analysis of furocoumarins present in P. alsaticum and P. cervia was performed by UPLC (ultra-performance liquid chromatography) using a colunrn packed with 1.7 pm Cl 8 [57]. 

A sensitive, specific, and rapid LC-MS method has been developed and validated for the simultaneous determination of xanthotoxin, psoralen, isoim-pinellin, and bergapten [80]. A paper by Zheng et al. [81] reported the quantitation of eleven coumarins including furocoumarins in Angelica dahurica, using HPLC-ESl-MS/MS. Yang et al. [82] developed a method for the characterization of linear furanocoumarins in Radix glehniae by LC-MS by the... 

GC has predominantly been used for the identification and quantitative analysis of furocoumarins in preparations and raw plant materials. The GC data can be used to determine the structure and estimate the retention time of analogous coumarins [54]. A number of methods have been described for the analysis of furanocoumarins using capillary GC [24,91]. A gas chromatographic method was used to determine osthole content in Fructus Cnidii extract, with a DBTM-5 column a flame ionization detector FID [92]. The analysis of psoralen, bergapten, pimpinellin, and isopimpineUin has been carried out by GC-FID with a capillary fused silica [71]. 

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