Furan, 2-methyl-5-nitro

Furan, 2-methyl-5-trifluoromethyl- H NMR, 4, 558 <68JHC95>, 558 <68JHC95> Furan, 2-nitro-... 

The effect of substituents on the reactivity of heterocyclic nuclei is broadly similar to that on benzene. Thus mem-directing groups such as methoxycarbonyl and nitro are deactivating. The effects of strongly activating groups such as amino and hydroxy are difficult to assess since simple amino compounds are unstable and hydroxy compounds exist in an alternative tautomeric form. Comparison of the rates of formylation and trifiuoroacetylation of the parent heterocycle and its 2-methyl derivative indicate the following order of sensitivity to substituent effects furan > tellurophene > selenophene = thiophene... 

H NMR, 5, 558 <71BSF990) Furan-2-carbaldehyde, 4-methoxy- H NMR, 4, 558 <7IBSF990) Furan-2-carbaldehyde, 5-methyl- C NMR, 4, 565 (76AJCI07) Furan-2-carbaldehyde, 5-nitro-UV, 4, 588 <50JA753)... 

Furan, 2,3-dihydro-5-methyl-polymers, 1, 276 Furan, 2,3-dihydro-3-methylene- H NMR, 4, 577 Furan, 2,5-dihydro-2-methylene- H NMR, 4, 577 tautomerism aromaticity and, 4, 595 Furan, 2,5-dihydro-2-nitro-structure, 4, 550 Furan, 2,3-dihydroxy-tautomerism, 4, 37 Furan, 2,4-dihydroxy-tautomerism, 4, 37 Furan, 3,4-dihydroxy-tautomerism, 4, 37 Furan, 2,5-diiodo-nitration, 4, 602 synthesis, 4, 712 Furan, 3,4-diiodo-reactions, 4, 650 Furan, 2,3-dimethoxy-synthesis, 4, 625, 648 Furan, 2,5-dimethoxy-synthesis, 4, 648 Furan, 3,4-dimethoxy-cycloaddition reactions, 4, 64, 625 lithiation, 4, 651 reactions... 

Furan-2-carbaldehyde, 5-methyl-synthesis, 4, 658 Furan-2-carbaldehyde, 5-nitro-as chemotherapeutic agent, 1, 179... 

Sequential Michael additions are versatile methods for the construction of cyclic compounds. Although a variety of these reactions have been developed, the use of alcohols as nucleophiles for the Michael addition to nitroalkenes has been little studied. Recently, Ikeda and coworkers have reported an elegant synthesis of octahydrobenzo[b]furans via the sequential Michael addition of 1-nitro-cyclohexene with methyl 4-hydroxy-2-butynoate in the presence of t-BuOK followed by radical denitration (Eq. 7.74).94... 

The nitration of l-methyl-2-(2-furyl)- and l-methyl-2-(2-thienyl)imidazoles in polyphosphoric acid was described [149, 150], At room temperature the nitro group enters at position 5 both of the furan and of the thiophene rings. Nitration of the furan derivative by 2 moles of nitric acid leads mainly to the dinitro derivative l-methyl-2-(5-nitro-2-furyl)-5-nitroimidazole [149], The introduction of a second nitro group into the thienyl derivative requires more rigorous conditions (80°C, 2 moles of nitric acid). Its position in the imidazole ring was not established [150],... 

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