Fungicides biochemical approach

Serendipity in the traditional screening approaches is, up to now, one of the main resources for discovering acaricides with novel biochemical and physiological targets [2]. Based on the discovery that fungicidal phenylhydrazide compounds had some acaricidal activity, a synthesis program was initiated in Crompton Co. Research in 1990. From among several hundred carbazate derivatives synthesized and evaluated for acaricidal activity the methoxy-biphenyl-substituted carbazate (bifenazate. Fig. 30.2.1, Table 30.2.1) was selected for development [3]. 

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