Fungicides Acting on Mitosis and Cell Division

Zoxamide, an AntitubuMn Fungicide for Control of Oomycete Pathogens 

Zoxamide (1) [3,5-dichloro-N-(3-chloro-l-ethyl-l-methyl-2-oxopropyl)-4-methyl-benzamide, RH-7281, Fig. 16.1.1] was discovered and commercialized by Rohm and Haas Company in 2001 for control of Oomycete pathogens [1], and is now marketed by Dow AgroSciences LLC. The primary markets for zoxamide are late blight on potatoes and downy mildews on vines and vegetables. Inhibitors of microtubule assembly that have been used as fungicides include the benzimidazole (BZ) and thiophanate fungicides such as carbendazim and thiophanate-methyl, the N-phenylcarbamate (NPC) diethofencarb, and the antibiotic griseofulvin. Zoxamide represents the first inhibitor of microtubule assembly to be used commercially for control of Oomycetes. 

Microtubules are hollow filaments of the cytoskeleton composed primarily of tubulin, a dimeric protein consisting of a- and y -subunits, each of which is ap- 

Modem Crop Protection Compounds. Edited by W. Kramer and U. Schirmer Copyright 2007 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31496-6 

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