Fungi clinically important

To the best of our knowledge, there are no fungi of clinical importance within the Uredinales. 

This book addresses not only clinicians who want to learn more about clinically important fungi, but also allergologists, mycologists, biologists and lawyers concerned with the increasing number of lawsuits because of fungal spores in indoor air, which are claimed to be a major reason for sick building syndrome . 

Semisynthetic y0-lactam antibiotics with a 1,2,4-triazolyl substituent have been prepared and are in clinical use. However, the most important application of 1,2,4-triazoles is as biocides. 3-Amino-1,2,4-triazole (amitrole, amizol) is an unselective herbicide. Triadimenol 4 is one of the most effective fungicides. Its configuration IS, 2R) is essential for its action [162]. The 1,2,4-triazole fungicides inhibit the biosynthesis of ergosterol in fungi. 

Amphotericin B is the most important clinically and best defined chemically of the macrolide heptaene antibiotics. A fermentation product of the soil actinomycetes Streptomyces nodosus, amphotericin B binds selectively to ergosterol in the cell membrane of susceptible fungi, inducing changes in permeability that can produce lethal cell injury [50]. 

---