Fungal squalene epoxidase inhibitors

Figure 10 Selective growth inhibition ofS. pombe JY266 and RSE strains by terbinafine and tolnaftate (inhibitor of fungal squalene epoxidase) and by NB-598 (inhibitor of mammalian squalene epoxidase). Strain JY-266 possesses the fungal squalene epoxidase gene and transformant strain RSE possesses fungal and rat squalene epoxidase genes.

SBI class IV includes squalene epoxidase inhibitors that are actually not used as agricultural fungicides. Fungal squalene epoxidases are only very distantly related to their mammalian and higher plant counterparts in the phylogenetic tree [115] and are therefore principally suited as target of selective antimycotics as well as of... 

Terbinafme (Fig. 5.171), a member ofthe allylamine class ofantimycotics, is an inhibitor of the enzyme squalene epoxidase in fungal ergosterol biosynthesis. Terbinafme is orally active, is fungicidal and is effective against a broad range of dermatophytes and yeasts. It can also be used topically as a cream. 

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