Fungal resistance types

Nilsson, T., Rowell, R.M., Simonson, R. and Tillman, A.-M. (1988). Fungal resistance of pine particle boards made from various types of acetylated chips. Holzforschung, 42(2), 123-126. 

This is not discussed in detail since mechanisms of resistance have been carefully reviewed (Ghannoum and Rice 1999). It was pointed out that resistance has not been associated with modification of the structure. For the 1,2,4-triazoles that have been widely used, their effect is due to inhibition of the synthesis of ergosterol that is the dominant component of fungal cell membranes. Resistance is generally associated with modification of the target enzymes, for example, the epoxidation of squalene (Terbinafine) or 14a-demethylase (Fluconazole). Resistance of Candida albicans to the azole antifungal agent fluconazole demonstrated, however, the simultaneous occurrence of several types of mechanism for resistance (Perea et al. 2001) ... 

Polyurethane elastomers are exceptionally tough, abrasion resistant, and resist attack by oil. The polyester types (AU) are susceptible to hydrolytic attack at above ambient temperatures, and certain polyester thermoplastic polyurethanes have been known to stress crack in cable jacketing applications when in contact with water at ambient temperatures this latter effect has sometimes, incorrectly, been ascribed to fungal attack. Polyether types (EU) are far more resistant to hydrolytic attack. Certain polyurethanes can be attacked by UV light, the resistance to this agency primarily being determined by the isocyanate used. 

A total of 250 fungal isolates were obtained in pure culture. Colony morphologies of many of the isolates were similar. On the basis of colony morphology on standard mineral base medium, organisms were separated into 59 types. These types were retained in stock to examine metal resistance characteristics and their ability to exocellularly modify Ni form and solubility in soil. Further classification to the species level is underway. 

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