Functions of the Dicarboxylic Acids

Transamination and the Integrative Functions of the Dicarboxylic Acids in Nitrogen Metabolism Alexander F. Braunstein... 

Diacylation products should be obtained by acylation reactions with dicarboxylic acid dichlorides. We carried out the reaction of methyl 10-undecenoate [2b] with adipic acid dichloride and EtA.lCl2 in a ratio of 2 1 4 (Scheme 3). After a reaction time of 2 h at room temperatoe, the product was crystallized from petroleum ether/ether (9 1) and identified as the methyl diketocarboxylate [9]. The aeylation took place at only one acyl chloride functionality of the dicarboxylic acid. The second acyl chloride functionality reacted with one equivalent of EtAlCl2in a Grignard analogous reaction to give the ethyl ketone. 

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