Functional groups hydrogen-bonding capabilities

In inosine, the NH2 at C(2) on guanine is removed, thereby reducing the hydrogen-bonding capability by a donor group with two functional hydrogens. 8-Bromoinosine is a rare example where the self-association of the purine residues occurs in the crystal structure of a nucleoside. 

The considered functional groups are those having some hydrogen-bonding capabilities that are essential for specific drug interactions with the target. These are called pharmacophore points and include amine, amide, alcohol, ketone, sulfone, sulfonamide, carboxylic add, carbamate, guanidine, amidine, urea, and ester. 

CTV can be used as a platform for attaching functional groups with hydrogen-bonding capability for anion binding. 

A number of ketones, pharmaceutical compounds, alcohols and hydroxy acids have also been resolved on this phase [724,765-767]. A chiral polysiloxane phase with tartramide substituents has been used for the separation of enantiomers capable of hydrogen bonding interactions with the stationary phase, such as enantiomers containing carboxylic, hydroxyl and amine functional groups [768]. 

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