Function-based discovery

Function-based discovery relies on good knowledge of the chemical reaction xmder study, which is necessary to elaborate a selection or screening strategy (Simon and Daniel, 2009). Sequence-based and function-based strategies can both benefit from enrichment steps in order to home in on functional microorganisms in a microbiome (Radajewski et al., 2000). 

Stockwell BR. (2000) Chemical genetics Ligand-based discovery of gene function. Nat. Rev. Genet. 1 116-125. 

Loots G, Ovcharenko I, Pachter L, Dubchak I, Rubin E. rVISTA for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res 2002 12 832-839. 

Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases Function-Based and Target-Based Discovery Approaches... 

As Kinter et al. (1994) reported, in many pharmacological laboratories prior to 1990, organ function testing was often conducted as an ancillary function of discovery research. The selection of specific studies for a candidate drug was based on concerns raised from its primary (those pharmacodynamic effects related to... 

Godemann R, Madden J, Kramer J et al (2009) Fragment-based discovery of BACE1 inhibitors using functional assays. Biochemistry 48 10743-10751... 

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