Full development treatment duration

For the treatment of hypertension and angina, the initial oral dose generally is 40-80 mg/day, titrated upward until the desired response is obtained, typically at <320 mg/day. In hypertension, the full antihypertensive effect may not develop for several weeks. If propranolol is taken twice daily for hypertension, blood pressure should be measured just prior to a dose to ensure that the duration of effect is sufficiently prolonged. Adequacy of adrenergic blockade can be assessed by measuring suppression of exercise-induced tachycardia. 

Hoheisel [20] 120 early treatment of beginning common cold mono purpurea herba placebo double 40% developed a "full" common cold in the treatment group vs. 60% with placebo duration of illness shorter ... 

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