Fucoxanthin apoptosis

Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., and Miyashita, K. 2004. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta 1675 113-119. 

Hosokawa, M., Wanezaki, S., Miyauchi, K., Kurihara, H., Kohno, H., Kawabata, J., Odashima, S., and Takahashi, K. 1999. Apoptosis inducing effect of fucoxanthin on human leukemia cell HL-60. Food Sci. Technol. Res., 5, 243-246. 

In addition. Das et ah demonstrated the effects of fucoxanthin on osteoclastogenesis. Treatment with 2.5 M fucoxanthin also induced apoptosis accompanied by activation of caspase-3 in osteoclast-like cells. Those in vitro studies suggest that fucoxanthin suppresses osteoclastogenesis via the inhibition of osteoclast differentiation and the induction of apoptosis in osteoclasts (Das et ah, 2010). Hence, dietary fucoxanthin may be useful for the prevention of bone diseases such as osteoporosis and rheumatoid arthritis, which are known to be related to bone resorption. 

Das, S. K., Ren, R., Hashimoto, T., and Kanazawa, K. (2010). Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells. /. Agric. Food Chem. 58, 6090-6095. 

Kotake Nara, E., Asai, A., and Nagao, A. (2005a). Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells. Cancer Lett. 220, 75-84. 

Inhibition of osteoclastogenic differentiation by ikarisoside A (Fig. 32.2C) in RAW 264.7 cells via JNK and NF-kB signaling pathways have been recently reported (Choi et al., 2010). Lucas et cd. (2003) studied the modulatory effect of bolinaquinone (Fig. 32.2D), a marine sesquiter-penoid, on acute and chronic inflammatory processes. Fucoxanthin (Fig. 32.2E) that induces apoptosis also induced osteoclast differentiation in a study conducted by Das et al. (2010). 

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