Frustum array device

To apply the concept of the hollow sphere to the frustum array device it is assumed that each frustum-shaped cell is the sector of a hollow sphere that is generated by a cone of revolution whose vertex coincides with the center of the spheres. Because the layer in which the frustums exist is impermeable to drug, there is no transport across the lateral areas of the frustums. Thus, Equations 1-3 apply and the area term for Equation 4 is given by the declina-... 

Buccal mucosa histology, 311-315 Burst period, frustum array drug delivery device, 332... 

A device consisting of an array of frustum-shaped cells that contain a drug dispersed in a permeable matrix is shown to obey zero-order release kinetics following an initial burst phase. Geometric shapes of dissolving solids or diffusion systems and the constraints of impermeable barriers influence mass transport and can be exploited as in the constant release wedge- or hemispheric-shaped devices. 

Summary. A device comprised of an array of frustum-shaped cells in which drug was dispersed provided a release pattern having a burst phase followed by a constant release rate. This pattern results from the geometric shape of the cells. A mathematical model was developed to predict the release characteristics of this system. 

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