From Gene to Protein

Clearly, by tradition, chemoinformatics has largely dealt with small molecules, whereas bioinformatics has started to move from genes to proteins, compounds... 

Sklonick J et al. From genes to protein structure and function novel applications of computational approaches in the genomic era. TIBTECH 2000 18 34-39. 

Taylor, P. and Radic, Z. The cholinesterases from genes to proteins. Annu. Rev. Pharmacol. Toxicol. 34 281-320, 1994. 

Scheme 1.1 From gene to protein structure via cell-free protein expression.

Most genes contain the information needed to make functional molecules called proteins. (A few genes produce other molecules that help the cell assemble proteins.) The journey from gene to protein is complex and tightly controlled within each cell. It consists of two major steps transcription and translation. Together, transcription and translation are known as gene expression. 

Nakashima, T., Fox, S. W. Model Ribosomes, in From Gene to Protein Translation into Biotechnology, The Fourteenth Miami Winter Symposium (eds.) Ahmad, F., Schultz, E. E., Whelan, W. J. p. 81, University of Miami, School of Medicine 1982... 

Schwarzbauer, J. E. (1991). Fibronectin From gene to protein. Curr. Opin. Cell Biol. 3, 786-791. 

After the basic principles of information transfer from genes to proteins had been established with the identification of messenger RNA, the discovery of the medianism of protein synthesis and the structure of genetic code, it was natural for some of us to ask whether the lessons learnt in molecular biology could be applied to the genetics of more complex phenotypes. ... 

F. Jacob and J. Monod [7]. Operator proposed as site where repressor binds to stop the flow of information from gene to protein. Regulator gene proposed. 

Of course, Seymour Benzer was also one of many at that time who were trying to elucidate the mechanism of information transfer from genes to proteins. However, he was very critical of what he called the rat race at that time he was no doubt unique. Later, whenever I was involved in a competitive race in science, I recalled his comments on the rat race and avoided being trapped by this danger that so often plagued many competent scientists. 

Filatov D, Ingemarson R, Johansson E, Rova U, Thelander L. 1995. Mouse ribonucleotide reductase from genes to proteins. Biochem Soc Trans 23 903-905. 

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