Friedal-Crafts alkylation

Friedal-Crafts Alkylations with Silicon Compounds... 

Davankov and his co-workers [55, 56] first discovered these remarkable resins. They are prepared either by chemically crosslinking linear polystyrene in a post-polymerisation treatment, or similarly post-treating lightly crosslinked (with —0.3-2% divinylbenzene) polystyrene resins. Reagent quantities are chosen to allow exhaustive Friedal-Crafts alkylation of aromatic... 

Suh et al.65 have reported a formal total synthesis of Mansonone F and this is described in Scheme 12. 5-Methoxy-a-tetralone (127) was converted to 1-methyl-5-hydroxy-naphthalene (128) by the standard organic reactions. Treatment of (128) with phenyl boronic acid, paraformaldehyde and propionic acid followed by catalytic hydrogenation yielded compound (129). This on alkylation gave the compound (130) which on alkaline hydrolysis was converted to acid. The acid halide underwent intramolecular Friedal-Crafts acylation affording an intermediate (131) whose transformation to Mansonone F has been accomplished by Best and Wege.59... 

Fluoro biphenyl methyl ketone may be prepared by the Friedal-Craft s acylation of 3-fluorobiphenyl with aeetyl ehloride whieh upon Wilgerodt reaetion followed by esterification yields the corresponding aeetie ester. This on treatment with sodium ethoxide and ethyl carbonate yields a malonate which on alkylation forms a monoethyl eompound. The resulting product on subsequent hydrolysis and concomitant decarboxylation yields flurbiprofen. 

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