Free radical pathology

Demopoulos, H.B., Flam, E.S., Peitronigro, D.D. and Seligman, M. (1980). The free radical pathology and the micro-circulation in the major central nervous system disorders. Acta Physiol. Scand. 492, 91-119. 

Formation of hydroxyl radicals has been suggested in many studies, which are considered in subsequent chapters in connection with the mechanisms of lipid peroxidation and protein and DNA destruction as well as the mechanisms of free radical pathologies. Furthermore, hydroxyl radical generation occurs under the conditions of iron overload and is considered below. 

Biological effects of SODs are widely studied in many in vitro, ex vivo, and in vivo experiments many of these studies have already been considered throughout this book. Examples of SOD application for the treatment of free radical pathologies are discussed in Chapter 31. Some studies related to the effects of SODs on free radical processes in cells and tissues are discussed below. 

Mahadik S. R and Mukherjee S. (1996). Free radical pathology and antioxidant defense in schizophrenia a review. Schizophr. Res. 19 1-17. 

V.Z. Lankin, V.l. Korchin, G.G. Konovalova and R.D. Jarkova, Alloxan-induced diabetes as a model of free radical pathology. Free Radic.Biol.Med. 16 (1994) 15. 

Atherosclerosis as a Free Radical Pathology and Antioxidative Therapy of this Disease... 

Free Radical Pathology Super-oxide Radical Superoxide Dismutases Irwin Fridovich 10, 257... 

In the present work, a combination of three chemiluminescence (CL) methods is used, based on lumino 1-dependent CL for registering antioxidant properties of ethanol extract of Crataegus oxycantha leaves and flowers. Sources of the most reactive ROS - hypochlorite and hydroxyl radical were used, as well as a HRP/H2O2 system. There is information that this plant favourably influences cardiovascular diseases and other conditions related to free-radical pathology.3 5 Regarding some other Crataegus species, information has been obtained that they show antioxidant activity in some model systems, which is one of the possible explanations of the curative effect of these herbs.6... 

Using the combination of these three CL methods we found that the extract from Crataegus oxycantha leaves and flowers has strong antioxidant properties with regard to some of the most active ROS. These properties of Crataegus oxycantha explain part of its favorable effects in the treatment and prophylaxis of diseases related to free radical pathology, such as the cardiovascular disease. 

Cranton, E.M. and Frackelton, J.P., Free radical pathology in age-associated diseases treatment with EDTA chelation, nutrition and antioxidants, J. Hoi Med., 6,6,1984. 

R. L. Willson, Zinc and Iron in Free Radical Pathology and Cellular Control in Zinc in Human Biology (C. F. Mills, ed.), Springer-Veriag, London, 1989. 

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