Frechet

J.M.J. Frechet (C. J. Hawker, 1990) replaced the divergent synthesis by a convergent growth of a dendritic polymer. The repeatedly employed monomer, 5-hydroxymethyl-l, 3-benzenediol, was 1,3-O-dibenzylatcd with 3,5-bis(benzyloxy)benzyl bromide. The resulting benzyl alcohol containing 7 benzene rings was converted to the benzyl bromide which was... 

E. C. Blossey and D. C. Neckers, Eds., Solid Phase Synthesis, Halsted, New York, 1975 P. Hodge and D. C. Sherrington, Eds., Polymer-Supported Reactions in Organic Synthesis, Wiley-Interscience, New York, 1980. A comprehensive review of polymeric protective groups by J. M. J. Frechet is included in this book. 

FIGURE l.l Hydrophobic interaction and reversed-phase chromatography (HIC-RPC). Two-dimensional separation of proteins and alkylbenzenes in consecutive HIC and RPC modes. Column 100 X 8 mm i.d. HIC mobile phase, gradient decreasing from 1.7 to 0 mol/liter ammonium sulfate in 0.02 mol/liter phosphate buffer solution (pH 7) in 15 min. RPC mobile phase, 0.02 mol/liter phosphate buffer solution (pH 7) acetonitrile (65 35 vol/vol) flow rate, I ml/min UV detection 254 nm. Peaks (I) cytochrome c, (2) ribonuclease A, (3) conalbumin, (4) lysozyme, (5) soybean trypsin inhibitor, (6) benzene, (7) toluene, (8) ethylbenzene, (9) propylbenzene, (10) butylbenzene, and (II) amylbenzene. [Reprinted from J. M. J. Frechet (1996). Pore-size specific modification as an approach to a separation media for single-column, two-dimensional HPLC, Am. Lab. 28, 18, p. 31. Copyright 1996 by International Scientific Communications, Inc.. Shelton, CT.]... 

Frantisek Svec, Dirk Wulff and Jean M. J. Frechet... 

Miller RD, Hofer D, McKean DR, Willson CG, West R, Trefonas P (1984) in Materials for Microlithography, Thomson L, Willson CG, Frechet JMJ (eds), ACS Symposium Series 266, American Chemical Society, Washington, DC... 

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