Framework analysis

Fig. 4.15 Hit list from Feature Tree fragment space searches are grouped by a molecular framework analysis (y-axis) and the Feature Tree similarity score (x-axis). The search algorithm indeed produces compounds from...

We would like to thank Dirk Tomandl (Santhera Pharmaceuticals) for stimulating discussions, molecular framework analysis and cheminformatics support. Thanks are also due to Marcus Gastreich (BioSolvelT) for his assistance in the CDK2 virtual screening experiment and for his general advice on chemistry matters. Finally we would like to thank Christian Lemmen (BioSolvelT) for many valuable suggestions on the manuscript. 

Application of this topological framework analysis to ion channel modulators yields access to privileged ion channel chemotypes. Conversion of these frameworks into appropriate scaffolds for synthesis allows subsequent building of ion channel focused libraries. 

FRAMEWORK ANALYSIS FOR DETERMINING MODE OE ACTION AND HUMAN RELEVANCE... 

CHAPTER 13 FRAMEWORK ANALYSIS FOR DETERMINING MODE OF ACTION TABLE 13.6. Concordance Analysis of Key Events in Humans for Dichloromethane... 

From the viewpoint of national economic development, complete appraisal of a project should encompass at least six areas of analysis sectoral framework market analysis process technology project scope management and persoiineI -and finance and econom--ics [1]. Sectoral framework analysis assesses the impact of sectoral and macroeconomic policies on the project and the impact of the project on sectoral development. This chapter is not intended to provide a complete guide-... 

The errors encountered with a given level of theory in calculation of vibrational intensities are considerably more profound than those in the frequencies. Meaningless results are common unless the basis set is of double-C quality and contains polarization functions. The double-harmonic approximation is another source of error. Nonetheless, the effects of H-bonding upon the intensity of each mode can be profitably studied within this framework. Analysis of these intensities sheds light upon the electronic density perturbations caused by formation of the bond. 

Shehane, R., Huan, X., and Ali, A. 2011, August. A framework analysis of the action plan for import safety. Journal of International Business and Cultural Studies, 5 1-19. 

---