Frameshift mutagenesis

LaVelle JM. 1986b. Potassium chromate potentiates frameshift mutagenesis in E. coli and S. typhimurium. MutatRes 171 1-10. 

Efficient error-free nucleotide insertion opposite an AAF-dG adduct can be catalyzed by Polr in vitro. The human Polr is more efficient in subsequent extension synthesis as compared to the yeast Polq. If the error-free translesion synthesis activity of Polr is utilized in cells in response to AAF-dG adducts, this polymerase would function to suppress AAF-induced mutagenesis. In one study with yeast cells, both an error-free bypass role and a frameshift mutagenesis role of Polq were reported. Hence, it is still unknown about the contribution of Polq to AAF-induced mutagenesis. Opposite a template AAF-dG adduct, human Poll is able to insert predominantly a C in vitro. Subsequent extension synthesis, however, was not observed. 

Rodriguez, H., and Loechler, E. L. (1995). Are base substitution and frameshift mutagenesis pafliways interrelated An analysis based upon studies of flie frequencies and specificities of mutations induced by the (+)-anti diol epoxide of benzo[a]pyrene. Mutat Res 326, 29-37. 

Milhe, C., Fuchs, R.P., and Lefevre, J.F. (1996) NMR data show that the carcinogen N-2-acetylaminofluorene stabilises an intermediate of -2 frameshift mutagenesis in a region of high mutation frequency. Bur. J. Biochem., 235,120-127. 

Broschard, T.H., Koffel-Schwartz, N., and Fuchs, R.P.P. (1999) Sequence-dependent modulation of frameshift mutagenesis at the Narl-derived mutation hot spots. 

Gill, J.P. and Romano, L.J. (2005) Mechanism for N-acetyl-2-aminoflu-orene-induced frameshift mutagenesis by Escherichia coli DNA polymerase I (Klenow fragment). Biochemistry, 44, 15387-15395. 

The compound bergapten was found to induce lethal and mutagenic photosensitization of bacteria, "dark"-induced frameshift mutagenesis in bacteria, and lethal and clastogenic effects on mammalian cells in tissue cultures (Ashwood-Smith et al. 1980). 

Mutagenesis studies showed that this type of mutation induced a -1 frameshift. A further report describes the incorporation of an (adjacent) cis-syn cyclobutane dimer site specifically into a nucleosome The templating properties of the thymine photoproducts, including the Dewar photoproduct (176), have been examined using the pyrene C-nucleoside triphosphate. The pyrene nucleotide was inserted in preference to dATP opposite the 3 -T of the photoproducts in all cases except for a trans,syn photoproduct, whereas dATP was preferentially incorporated opposite the 5 -T in all cases. This suggests that the incorporation opposite the 3 -end of the photoproduct takes place via a transient abasic site-like intermediate. 

Reuven, N. B., Tomer, G., and Livneh, Z. (1998). The mutagenesis proteins UmuD and UmuG prevent lethal frameshifts while increasing base substitution mutations. Mol. Cell 2, 191-199. 

T. Kada, M. Moriya, and Y. Shirasu, Screening of pesticides for DNA interactions by rec-assay and mutagenesis testing, and frameshift mutagens detected, Mutat. Res. 26, 243... 

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