Fragmentor voltage

Fragmentor voltage Over 220 V Under 90 V 110-150V Collision-induced dissociation effect Poor ionization efficiency Good ionization efficiency... 

Fragmentor voltage Another term for cone-voltage fragmentation. 

A sensitive and rapid chromatographic procedure using a selective analytical detection method (electrospray ionization-mass spectrometry in SIM mode) in combination with a simple and efficient sample preparation step was presented for the determination of zaleplon in human plasma. The separation of the analyte, IS, and possible endogenous compounds are accomplished on a Phenomenex Lima 5-/rm C8(2) column (250 mm x 4.6 mm i.d.) with methanol-water (75 25, v/v) as the mobile phase. To optimize the mass detection of zaleplon, several parameters such as ionization mode, fragmentor voltage, m/z ratios of ions monitored, type of organic modifier, and eluent additive in the mobile phase are discussed. Each analysis takes less than 6 min. The calibration curve of zaleplon in the range of 0.1-60.0 ng/ml in plasma is linear with a correlation coefficient of >0.9992, and the detection limit (S/N = 3) is 0.1 ng/ml. The within- and between-day variations (RSD) in the zaleplon plasma analysis are less than 2.4% (n = 15) and 4.7% (n = 15), respectively. The application of this method is demonstrated for the analysis of zeleplon plasma samples [14]. 

S. N. Pedersen, K. A. Francesconi, Liquid chromatography electrospray mass spectrometry with variable fragmentor voltages gives simultaneous elemental and molecular detection of arsenic compounds, Rapid Common. Mass Spectrom., 14 (2000), 641-645. 

Fragmentor voltage 80 V Gas temperature 350 °C Drying gas 10 1/min Nebuliser pressure 40 psig Capillary voltage 4000 V... 

Using a high fragmentor voltage of 290 V, BADGE and its derivatives were detected using specific ion monitoring at m/z 211 (Eig. 16.2). Some differences in sensitivity were observed as shown in Eig. 16.3. 

Thiabendazole showed a protonated molecule at m/z 202 in positive-ion APCI and ESI [19, 23], At higher fragmentor voltages, a fragment due to the loss of HCN was observed [19]. 

Vinclozolin, procymidone, iprodione, and 3,5-dichlorophenyl hydan-toin (the iprodione degradation product) in wine were determined by SBSE and negative-ion liquid desorption-APCI (fragmentor voltage 70V, capillary voltage 4000V, mass range m/z 200-350) (Sandra et al.,... 

Fragmentor voltages 20V positive mode, -40V negative mode (Fernandez et al., 2000). 

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