Fragmentation of markets

Vieth M, Siegel MG, Higgs RE, Watson lA, Robertson DH, Savin KA, et al. Characteristic physical properties and structural fragments of marketed oral drugs. J Med Chem 2004 47 224-32. 

Veith, M., Siegel, M.G., Higgs, R.E. et al. (2004) Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs. Journal of Medicinal Chemistry, 47, 224-232. 

For the moment, then, it is not appropriate to talk of a world pharmaceutical market as such, as there are fragmented domestic markets corresponding to each country s geographical boundaries, each characterized by its own system of price regulation and intervention. 

Fluoro Analogues of Antitumour Natural Products Valmbidn (trifluoroacetyladriamycin valerate) (Valstar ), an ester of adriamycin trifluoroace-tylated on the aminoglycosidic fragment, is marketed for the treatment of resistant bladder cancer (Figure 8.7) (cf. Chapter 4). 

Shan and the lowest prices in the main cultivation areas South and East Shan. The regional price differences seem to reflect well the scarcity or availability of opium in different regions, as well as the fragmentation of the opium market caused by opium bans in some regions. 

About 70% of PB production is used for the manufacturing of pipes for cold and hot water supply, and under-floor heating pipes. The remaining 30% of the production volume includes butene/ethylene random co-polymers and finds application in highly specialized and fragmented specialties markets, such as components in easy-peel films, process aids, and many others.878... 

The PCR is another case with a huge potential market. The PCR method is commonly used to create copies of specific fragments of DNA. First, the individual strands of DNA are unwoimd and separated by heating to 90-96°C. Then, the DNA is cooled to 50-60°C so that primers can bind to the DNA. The primers allow the duplication process to start at a specific point on the DNA. Finally, the temperature is raised to 72°C and Tfl -polymerase is used to grow two strands of DNA for the original single strand. Generally, the cycle is repeated perhaps 30 times to produce a factor of 2 ° increase in DNA concentration. 

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