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Fragment-based drug design FBDD

Recently, fragment based drug design (FBDD) has emerged as a popular structure based approach to lead discovery. Despite the success of FBDD for myriad proteins, the thermodynamic basis for its success remains elusive. Using stromelysin-1 (MMP-3) as a model system and two previously described ligands, we have characterized extensively the thermodynamic principles of additivity and cooperativity in the context of FBDD. The results of these studies and their implications for drug discovery will be discussed. [Pg.21]

The design of a robust fragment-based drug discovery (FBDD) process can lead to large increases in productivity in lead generation and lead optimization.161 It should be noted that... [Pg.15]

See other pages where Fragment-based drug design FBDD is mentioned: [Pg.241]    [Pg.242]    [Pg.25]    [Pg.187]    [Pg.360]    [Pg.197]    [Pg.197]    [Pg.241]    [Pg.242]    [Pg.25]    [Pg.187]    [Pg.360]    [Pg.197]    [Pg.197]    [Pg.126]    [Pg.229]    [Pg.83]    [Pg.229]    [Pg.308]    [Pg.10]    [Pg.417]    [Pg.747]    [Pg.23]    [Pg.91]    [Pg.217]   
See also in sourсe #XX -- [ Pg.25 , Pg.26 , Pg.417 ]



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