Foundation of Quantitative Method Development

The characteristics of the NIR spectrum require the use of multivariate calibration techifiques in order to establish a quantitative relationship between the spectrum and the chemical (composition) and/or physical parameters (particle size, viscosity and density) of the sample. 

Calibration is the process by which a mathematical model relating the response of the analytical instrument (a spectrophotometer in this case) to specific quantities of the samples is constructed. This can be done 

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