Fosinopril properties

Monopril fosinopril. monosulfiram [ban] (sulfiram [inn]) is an ethylthiocarbonic acid derivative with ANTIFUNGAL properties and can be used as parasiticide and fungicide, montelukast [ban, inn] (montelukast sodium [usan] Singulair ) is a chloroquinolinyl derivative, a (LTD ) LEUKOTRIENE receptor antagonist, which can be used as an ANTIASTHMATIC. 

An example of this approach is shown in Figure 12.7. During the preparation of the fosinopril sodium intermediate 3 about 2% of the regioisomeric impurity 6 was formed [41]. Compounds 3 and 6 are too similar to be readily separated based on their chemical properties, and it was hoped that through purification of the subsequently derived intermediates, no regioisomer-derived impurities would be carried along to the final product. Since 3 is a low-melting solid and was isolated as a solid residue, no purification by crystallization was readily available. 

Fosinopril, an ACE inhibitor with antihypertensive properties (10 mg p.o. daily), is used in the treatment of hypertension (see also Figure 24). 

Brittain, H. G., Morris, K. R., Bugay, D. E., Thakur, A. B. and Serajuddin, A. T. M. Solid state characterization of fosinopril sodium polymorphs. J. Pharm. Biomed. Anal. 11 1063, 1993. Geppi, M., Guccione, S., Mollica, G., Pignatello, R. and Veracini, C. A. Molecular properties of ibuprofen and its solid dispersions with Eudragit RLIOO studied by solid-state nuclear magnetic resonance. Pharm. Res. 22 1544-1555, 2005. 

---