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Fosfluconazole

TRIAZOLE ANTIFUNGALS ITRACONAZOLE (SPORANOX ), FLUCONAZOLE (DIFLUCAN ), VORICONAZOLE (VFEND ), AND FOSFLUCONAZOLE (PRODIF )... [Pg.71]

USAN Fosfluconazole Trade name Prodif Pfizer... [Pg.71]

Although fosfluconazole is some 25-fold less active than fluconazole in vitro, it is rapidly hydrolyzed by phosphatases in vivo and has similar efficacy in animal models and in patients, where it is 97% bioavailable (Hegde and Schmidt, 2005). The prodrug has a half-life of 2.3 h in patients, and the vast majority of the dose is excreted as fluconazole. Consequently, fosfluconazole has a similar clinical profile to that of fluconazole. [Pg.80]

A number of synthetic routes to fosfluconazole (4) have been described (Scheme 5.5) (Bentley et al., 2002). The initial small-scale route used conditions described by Fraser-Reid involving treatment of fluconazole (2) with dibenzyl diisopropylphosphoramidate in... [Pg.80]

See other pages where Fosfluconazole is mentioned: [Pg.589]    [Pg.607]    [Pg.590]    [Pg.609]    [Pg.80]    [Pg.80]    [Pg.29]    [Pg.495]    [Pg.495]    [Pg.589]    [Pg.607]    [Pg.590]    [Pg.609]    [Pg.80]    [Pg.80]    [Pg.29]    [Pg.495]    [Pg.495]   
See also in sourсe #XX -- [ Pg.71 , Pg.80 ]

See also in sourсe #XX -- [ Pg.29 ]



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Synthesis of Fosfluconazole

TRIAZOLE ANTIFUNGALS ITRACONAZOLE (SPORANOX), FLUCONAZOLE (DIFLUCAN), VORICONAZOLE (VFEND), AND FOSFLUCONAZOLE (PRODIF)

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