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10-Formyltetrahydrofolic acid

Leucovorin or folinic acid, a mixture of the 6R- and 6S,-diastereomers of 5-formyltetrahydrofolic acid, is an important clinical agent which may be used as a remedy for megaloblastic anemia and as an antidote for inadvertent overdosages of antifolates in patients with cancer, parasitic diseases, or autoimmune disorders such as psoriasis and rheumatoid arthritis. In view of these applications it is surprising that few significant improvements in the manufacture of leucovorin have occurred... [Pg.726]

FoNiiic add /V-[(65)-5-formyl-5,6,7,8-tetrahydropte-royl]-L-glutamic acid, (6S)-5-formyltetrahydrofolic acid, leucovorin. ... [Pg.238]

SCHEME 22.4 Hydrogenation of folic acid and fnrther formylation to 5-formyltetrahydrofolic acid. [Pg.546]

D. Greenberg, N5-Formyltetrahydrofolic acid cyclohy-drase. In Methods in Enzymology, XVIII, Part B (eds. D. B. McCormick and L. D. Wright), Academic Press,... [Pg.348]

Folinic acid (A/ -formyltetrahydrofolic acid). A/ .Af -methyl-enctetrahydrofolic acid, and At -fomiyltetrahydrofolic acid... [Pg.270]

FoUnic acid can be formed along with A i -formyltetrahydrofolic acid by direct formylation of 5,6,7,8-tetrahydrofolic acid. Both tetra- and di-hydro-... [Pg.99]

It is of interest that many of the reduced folic derivatives prepared as a result of chemical studies of growth factors have subsequently been foimd to serve directly as coenzymes in the transfer of single carbon units. Reversible enzymatic transfer of the single carbon unit from anhydrofolinic acid to glycineamide ribotide, from Ai -formyltetrahydrofolic acid to 5-amino-4-imidazolecarboxamide ribotide, and from folinic acid to glutamic acid have been observed to be specific for these respective formyl donors -. ... [Pg.100]

The imidazolinium ring is opened by an enzyme, cyclohydrolase, to form ATi< -formyltetrahydrofolic acid. This product does not absorb much light above 300 m, but has an absorption peak near 260 m. Both the... [Pg.275]

See other pages where 10-Formyltetrahydrofolic acid is mentioned: [Pg.421]    [Pg.37]    [Pg.164]    [Pg.389]    [Pg.164]    [Pg.280]    [Pg.98]    [Pg.257]    [Pg.348]    [Pg.429]    [Pg.184]    [Pg.391]    [Pg.546]    [Pg.547]    [Pg.313]    [Pg.421]    [Pg.421]    [Pg.421]    [Pg.37]    [Pg.317]    [Pg.88]    [Pg.164]    [Pg.294]    [Pg.917]    [Pg.1454]    [Pg.389]    [Pg.44]    [Pg.88]    [Pg.164]    [Pg.294]    [Pg.410]    [Pg.280]    [Pg.541]    [Pg.520]    [Pg.282]    [Pg.283]    [Pg.98]    [Pg.257]    [Pg.239]    [Pg.348]    [Pg.4894]    [Pg.296]    [Pg.429]    [Pg.429]    [Pg.431]    [Pg.275]    [Pg.319]    [Pg.319]    [Pg.184]    [Pg.13]   


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