Formyl peptide receptor fMLF with

Although other chemoattractant factors have temporarily taken a back seat to the intense interest in chemokines, they play unique and important roles in host defense. Obviously, small tripeptides such as fMLP derived from bacterial cell walls can potentially serve as an early warning signal that attract phagocytic cells to sites of infection. Comparisons of the attractive potency of fMLP, C5a, and pro-inflammatory chemokines reveal the former to be more potent and to deviate phagocyte migration away from chemokines (Campbell et al., 1996). It should be noted that a number of formylated peptides like fMLF are chemotactic, but fMLP has been studied most intensively as a prototype (Schiffmann et al., 1978). Two receptors, one with high and the other with lower affinity for fMLP, have recently been cloned. 

Fig. 2.2.6. Formyl peptide receptor-targeting peptide (fMLF)[(SAACQ-M(C0)3) ] conjugate useful for in vitro fluorescent microscopy (where M = Re) and in vivo single-photon emission computer tomography (SPECT) (where M = Tc) with isostructural technetium and rhenium complexes...

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